Let me begin by stating that this section will not cover every possible poison recipe. There are hundreds (if not thousands, by now) of these, and a far better resource for the seriously poison-minded rogue is EQ Traders. Nor will this section be any sort of diary of my own journey in learning the crafting of poisons; I won't inflict upon anyone else my chosen path of collecting and storing ingredients for months in advance.
What I will cover here are the basics.
As stated on the FAQ, a young rogue may begin his poison-making career at level 20. (He may apply poisons made by others as early as level 18, however.) In order to create a vial of poison, he must first obtain the appropriate container. His choices here are:
The rogue will then need to decide whether to make or purchase his poison vials. For the sake of comparison, I'll list the pottery trivials and vendor costs for each type:
Once in possession of some type of mortar and pestle, the rogue need only open this container and combine 1 vial, 1 suspension, and any other ingredients called for by the recipe.
Skilling Up without Farming
For rogues who are thin on time and fat of purse, the following is a suggested skill-up path:
Spirit of Sloth
Beyond 275, all poison recipes require at least one dropped item.
The rogue who is slightly more frugal but still wishes to avoid farming ingredients may prefer to take the following path: "Help Uiyaniv" quest in Abysmal Sea (NPC to contact: Uiyaniv Tu`Vrozix) to 54; Anti-Element to 76; Atrophic Sap to 98; Aching Blood to 108; Calcium Rot to 172; Spirit of Sloth to 275. He should, however, bear in mind that an increased failure rate may negate his initial savings.
Once the rogue has created a vial of poison, he may apply it to his weapon by sitting down, placing the poison in a main inventory slot, and clicking on it. This will only work with a piercing weapon equipped in the primary hand, and will last until the rogue logs off or zones. Poisons thus applied will be used the next time he pierces (not backstabs) a foe with his main hand.